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| Videx and Videx EC are anti-HIV medications. They are in a category of HIV medications called nucleoside reverse transcriptase inhibitors (NRTIs). NRTIs prevent HIV from altering the genetic material of healthy T-cells. This prevents the cells from producing new virus and decreases the amount of virus in the body. Videx, manufactured by Bristol-Myers Squibb, was the second drug approved for the treatment of HIV, and was approved by the U.S. Food and Drug Administration in 1989. Videx or Videx EC must be used in combination with at least two other anti-HIV drugs. The preferred dose of Videx buffered tablets is two 100mg tablets twice a day (for people who weigh 132 pounds or more) or one 100mg tablet and one 25mg tablet twice a day (for people who weigh less than 132 pounds). It is also possible to take Videx once a day, although some experts still recommend the twice-daily dosing schedule (it has been studied more carefully in clinical trials). If Videx tablets are taken once a day, the correct doses are: two 200mg tablets once a day (for people who weigh 132 pounds or more) or three 100mg tablets once a day (for people who weigh less than 132 pounds). Babies and children can also take Videx, using the powder formulation that can be used to make a liquid solution. The dose depends on a baby's size or a child's weight. If you are caring for a child who is HIV-positive and has been prescribed Videx, be sure that you understand the correct dose to give the child. As a child grows, the dose of Videx will need to be increased on a regular basis. Videx buffered tablets must be taken on an empty stomach (not eating within two hours before or one hour after taking Videx). Food and many liquids can prevent Videx from being properly absorbed into the bloodstream. Videx should be taken with water. It should not be taken with acidic juices, soda, or milk. Videx buffered tablets should not be taken at the same time as other medications. Other medications should be taken two hours before or two hours after taking Videx. This is because the antacid buffer in Videx can affect the way other medications – such as the protease inhibitors – are broken down in the gut and absorbed into the bloodstream. Numerous studies have demonstrated that Videx is effective for the treatment of HIV when combined with other anti-HIV drugs, usually at least one other nucleoside reverse transcriptase inhibitor (NRTI) and either a protease inhibitor or non-nucleoside reverse transcriptase inhibitor (NNRTI). Videx should not be taken alone (as monotherapy) or with just one other anti-HIV drug. The United States Department of Health and Human Services (DHHS) lists Videx as an "alternative" NRTI for HIV-positive people starting anti-HIV treatment for the first time (Retrovir [AZT], Epivir [3TC],and Viread [tenofovir] are listed as "preferred" NRTI options). If Videx is used, the DHHS recommends combining it with either Epivir or Emtriva (FTC) plus the NNRTI Sustiva (efavirenz). The DHHS recommends against using Videx or Videx EC and Zerit (d4T) or Hivid (ddC) in the same drug combination. The risk of side effects, which are similar for Zerit, Hivid, and Videx/Videx EC, are increased when these drugs are used at the same time. Therapy with Videx can cause certain changes (mutations) in HIV's structure to occur. Some mutations will prevent Videx from working against HIV. Some studies suggest that HIV is much more likely to become resistant to Videx if it is already resistant to Retrovir (AZT), another NRTI. If HIV is not resistant to Retrovir, resistance to Videx may develop much more slowly. If HIV does become resistant to Videx, it will not likely be sensitive to Hivid (ddC), another NRTI. However, this is not the same the other way around: HIV that becomes resistant to Hivid may still be sensitive to Videx. If your viral load does not go undetectable or becomes detectable (and increases) while you are taking an anti-HIV drug regimen, your doctor can order a drug-resistance test to determine if your HIV has mutations that are causing resistance to Videx and to help you figure out which NRTIs your HIV is still sensitive to. Methadone, a drug frequently used to help people recovering from heroin addiction, can decrease the amount of Videx in the bloodstream. This can result in an anti-HIV drug regimen being less effective against HIV, which can cause drug resistance. Combining Videx with Zerit (d4T), another nucleoside reverse transcriptase inhibitor (NRTI), may increase the risk of developing lactic acidosis. This is especially true in HIV-positive pregnant women who take both of these drugs together. In turn, the U.S. Food and Drug Administration (FDA) has recommended that HIV-positive women not take these two drugs together while they are pregnant. Videx can cause inflammation of the pancreas (pancreatitis). Pancreatitis is a rare but serious side effect that can be life-threatening in some cases. Notify your doctor immediately if you develop symptoms of pancreatitis, including nausea, vomiting, diarrhea, and abdominal pain. You should avoid alcohol while you are taking Videx, as alcohol can increase the risk of damage to your pancreas. A common side effect of Videx is peripheral neuropathy, which can result in pain, tingling, numbness, or burning in the hands and/or feet. Stopping Videx and starting another NRTI that does not usually cause peripheral neuropathy – for example, Retrovir (AZT) or Ziagen (abacavir) – is often the best way to stop peripheral neuropathy. Other common side effects include stomach aches, nausea, diarrhea, dry mouth, and central nervous system effects (e.g., anxiety, headaches, trouble sleeping, irritability, and restlessness). Very often, these side effects improve within a few months/weeks of starting Videx. Damage to the eyes is another serious side effect that can be caused by Videx. This is more likely to occur in HIV-positive children taking Videx. Anti-HIV drug regimens containing NRTIs, including Videx and Videx EC, can cause increased fat levels (cholesterol and triglycerides) in the blood, abnormal body-shape changes (lipodystrophy; including increased fat around the abdomen, breasts, and back of the neck, as well as decreased fat in the face, arms, and legs), and diabetes. |
Videx is belongs to the family of drugs called an Antiviral drug which known as nucleoside reverse transcriptase inhibitor or NRTI and commonly used for the treatment and prevention of the symptoms of infection caused by the human immunodeficiency virus (HIV). Videx works by stopping the human immunodeficiency virus (HIV) virus from reproducing. Videx is used in the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS). HIV 'human immunodeficiency virus' attacks some of the cells that are vital to a healthy immune system, including the white blood cells known as T-helper cells or CD4 cells. AIDS 'acquired immune deficiency syndrome’ is a condition that sets in when the HIV virus has killed so many T-helper cells that the immune system is no longer able to recognize and react to attacks from everyday infections. HIV may also attack the nervous system. Videx always takes under doctor’s guidance. The recommended doses of Videx will be different for different patients, according to the requirements of each patient; you continue to take it for as long as your doctor prescribes, even if you do not feel an immediate benefit. Your doctor will start you on a low dose of Videx and gradually increase your dose. If you can not tolerate the recommended dosage, your doctor can prescribe a dose that sufficient for you. The generic name of Videx is Didanosine. Videx is being manufactured by Bristol-Myers Squibb Pharmaceuticals and available in tablets. Videx may also be used for relieve other conditions that determined by your doctor or consultant. Effects - How it works in the body Videx is belongs to the family of drugs known as an Antiviral drug which commonly used for the treatment and prevention of the symptoms of infection caused by the human immunodeficiency virus (HIV). Videx works by stopping the (HIV) virus from reproducing. AIDS (acquired immune deficiency syndrome) is caused by infection with HIV. This virus invades cells of the immune system, particularly the white blood cells known as CD4 T-helper lymphocytes. These cells normally work to activate other cells in the immune system to fight infection. HIV kills CD4 T-helper cells; over time the body becomes less able to fight the virus or subsequent infections. Once the virus is inside the CD4 T-cell it multiplies, viral multiplication involves the conversion of the virus genetic material, RNA, into DNA. Videx works by blocking the action of this enzyme, thereby interfering with the conversion of viral RNA into DNA. Videx stops the virus from multiplying. There is no cure for HIV, but Videx is one of medications which lowers the amount of virus in the body and slow down the progression of the disease from HIV to AIDS. Possible side effects during the uses of Videx:
Although certain medicines should not be used together at all, so its your responsibilities that tell your doctor or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also you tell your doctor or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or addicted to illegal drugs. These may affect the working mechanism of Videx. In these cases, your doctor may change the dose or teach precautions may be necessary. Therefore when you are taking Videx, it is most important that your doctor or health care professional know if you are taking any of the following or other drugs:
You shouldn’t use this medicine without consultation of doctor if you have an allergy to Videx or any other ingredients of this medicine. You shouldn’t use Videx without consultation of doctor if you are suffering to the kidney disease. You shouldn’t use Videx without consultation of doctor if you are suffering to the problem of liver disease and Hepatitis C or Hepatitis delta. You shouldn’t use Videx without consultation of doctor if you are suffering to the problem of Heart disease. You shouldn’t use Videx without consultation of doctor if you are suffering to the problem of high cholesterol. You shouldn’t use Videx without consultation of doctor if you are suffering to the problems of pancreatitis. You shouldn’t use Videx without consultation of doctor if you are suffering to the problems of gout. You shouldn’t use Videx without consultation of doctor if you are suffering to the problems of phenylketonuria. You shouldn’t use Videx without consultation of doctor if you are pregnant or plan to be pregnant. You shouldn’t use Videx without consultation of doctor if you are suffering to breastfeeding.
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