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Activella/ (Estradiol/Norethindrone) is designed for use in hormone replacement therapy. Activella (Estradiol/Norethindrone) is a form of estrogen with a substance that acts like progesterone. Activella (Estradiol/Norethindrone) relieves the symptoms of menopause, and can be prescribed to prevent osteoporosis in postmenopausal women. Activella is also used for vaginal atrophy.
Estrogen, when taken by itself, poses an increased risk of uterine cancer. The progestin (Norethindrone) in Activella largely counteracts this effect. Activella Side Effects: Activella side effects may include: Abdominal pain, breast tenderness and enlargement, depression, enlargement of uterine fibroids, headache, nausea, nervousness, skin reddening, urinary tract infection, vaginal inflammation, vomiting If Activella (Estradiol/Norethindrone) is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before taking Activella (Estradiol/Norethindrone) with the following medications: Acetaminophen (Tylenol) Aspirin Clofibrate (Atromid-S) Cyclosporine (Neoral) Morphine Seizure medications such as Dilantin, Tegretol, and phenobarbital Steroid medications such as prednisone (Deltasone) Rifampin (Rifadin) Temazepam (Restoril) Theophylline (Theo-Dur) Overdose of Activella (Estradiol/Norethindrone) is very unlikely but symptoms of overdose may include: Nausea, vomiting, vaginal bleeding The recommended dose of Activella (Estradiol/Norethindrone) is one tablet daily. Activella (Estradiol/Norethindrone) supplements your body with hormones to treat symptoms of hormonal deficiency associated with menopause. Activella (Estradiol/Norethindrone) can help keep your hormones in balance and your menopause-related symptoms under control. Activella (Estradiol/Norethindrone) provides the following benefits to postmenopausal women with an intact uterus: Relief of moderate to severe hot flashes and night sweats Relief of vaginal symptoms such as dryness and discomfort Prevention of postmenopausal osteoporosis Activella (Estradiol/Norethindrone) should be used only by women who have a uterus. Do not take Activella (Estradiol/Norethindrone) if you are pregnant, have recently given birth, have unusual vaginal bleeding, or have had a hysterectomy, certain types of cancer, blood clots, or a history of stroke, heart attacks, or liver disease. Estrogen/progestin therapy may increase the risk of heart attacks, strokes and blood clots. Prolonged therapy may also increase the risk of breast cancer. Activella (Estradiol/Norethindrone) is generally well tolerated. The most common side effect is breast tenderness. Others may include headache, irregular bleeding, back pain and nausea. Information about Estrogen Replacement Therapy: Estrogen replacement therapy typically doubles the chances of gallbladder disease. Notify your doctor if you experience pain, tenderness, or swelling in your abdomen. Estrogen replacement increases the risk of blood clots in the veins, especially during the first year of therapy. Call your doctor immediately if you experience any of the following warning signs: bulging eyes, changes in vision or speech, coughing up blood, dizziness, double vision, faintness, migraine, pains in the calves or chest, severe headache or vomiting, sudden shortness of breath, sudden vision loss, weakness or numbness of an arm or leg. Estrogen therapy sometimes causes high blood pressure, so be sure to get periodic checkups. In women prone to high blood lipid levels, estrogen can also cause a sharp spike in triglycerides, possibly leading to pancreatitis. Fluid retention is another possibility. If it develops, it can aggravate conditions such as asthma, epilepsy, heart disease, kidney disease, and migraine. Make sure your doctor knows if you have ever been diagnosed with depression. Treatment with the products should be discontinued if depression recurs. If you have diabetes, watch your blood sugar levels especially carefully. There's a chance that estrogen/progestin products may make diabetes worse. |